Role of Serum Ferritin in Predicting Outcomes of COVID-19 Infection Among Sickle Cell Disease Patients: A Systematic Review and Meta-Analysis

Role of Serum Ferritin in Predicting Outcomes of COVID-19 Infection Among Sickle Cell Disease Patients: A Systematic Review and Meta-Analysis

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Patients with sickle cell disease (SCD) are at higher risk of getting severe COVID-19 infection.This systematic review and meta-analysis aimed to determine the role of serum ferritin in predicting ICU admission and mortality among patients with SCD following COVID-19 infection.A systematic search was conducted in PubMed, Scopus, Web of Science, Embase, WHO COVID-19 database, ProQuest, and Cochrane Library for articles published between 1st December 2019 to 31st November 2021.Methodological quality was assessed using the Joanna Briggs x515ea-bh55-cb Institute (JBI) critical appraisal checklists.Eleven articles (7 cohorts and 4 case series) were included in this review.

Pooled mean serum ferritin level on admission was 1581.62 ng/mL while pooled proportion of ICU admission and mortality were 0.10 (95% CI 0.06; 0.16, prediction interval 0.

04; 0.23, p = 0.29, I2 = 17%) and 0.07 (95% CI 0.05; 0.

11, prediction interval 0.04; 0.12, p = 0.68, I2 = 0%) respectively.Meta-regression showed that serum ferritin did not predict for both ICU admission (regression coefficient = 0.

0001, p = 0.3523) and mortality (regression coefficient = 0.0001, p = 0.4029).Our analyses showed that serum ferritin may not be a useful marker to predict the outcomes of COVID-19 infection among patients with SCD.

More data are required to identify a reliable tool to identify patients with SCD who are at risk of getting severe h22a4 transmission COVID-19 infection.Systematic Review Registrationhttps://www.crd.york.ac.

uk/prospero/display_record.php?RecordID=287792, PROSPERO Registration: CRD42021287792.